Fatigue is prevalent and impactful in rheumatoid arthritis (RA). There is no standardized measure for its assessment nor data concerning the performance of PROMIS-Fatigue short forms (SFs) in people with RA. This study analyzed PROMIS Fatigue SF scores in RA patients across the range of disease activity in order to evaluate score validity. It was found that 4, 7, and 8-item PROMIS- Fatigue SF capture fatigue across the spectrum of RA disease activity in diverse groups of individuals and should be considered for use as patient-centered assessments of disease control and treatment efficacy.