In this study, Ogdie et al. report descriptives of patients diagnosed with Ankylosing Spondylitis (AS) in the United States. Among 235 respondents, women experienced worse disease severity. The most common symptoms that led to seeking medical care included back pain, joint pain, stiffness, and fatigue. The most commonly reported misdiagnoses were back problems, psychosomatic issues, and sciatica. The results highlight differences between men and women in initial symptom presentation, misdiagnoses, time to diagnosis of AS, and the impact of AS on work and relationships.